The article highlights significant scientific and technological breakthroughs of 2024, focusing on advancements in medicine, space technology, and artificial intelligence. Key achievements include Gilead's HIV preventive drug, lenacapavir, which showed exceptional efficacy in trials; SpaceX's successful rocket-catching technology; Google's quantum computer solving complex problems; and innovations in generative AI, particularly in biology with the new AI model Evo. These developments demonstrate incremental improvements that could lead to profound future impacts.